Job Description

Associate Scientist - iPSC-Derived Neuron Models

12 month contract

On-site in Lexington, MA

Must be able to work on a W2

JOB DESCRIPTION:

Position Summary:

We are seeking a highly motivated and detail-oriented scientist to join our Humanized In Vitro Model Development team. The successful candidate will contribute to the development of human iPSC-derived neuronal models and assays to support drug discovery and translational research. This is an exciting opportunity to work at the forefront of human-relevant neuroscience in a collaborative and innovative environment.

TOP SKILLS:

1. Human iPSC-derived neuron culture experience

2. Gene perturbations using siRNA and/or CRISPR

3. Cell-based molecular and biochemical assays including 1) immunocytochemistry, 2) qPCR, 3) ELISA, 4) micro-electrode array (MEA), and 5) fluorescence microscopy (at least 2-3 of these 5 skillsets).

Key Responsibilities:

Culture, differentiate, and maintain human iPSC-derived neurons.

Perform routine cell-based and molecular assays including immunocytochemistry, qPCR, ELISA, MEA, luciferase, western blot, and fluorescence microscopy.

Conduct functional gene perturbations and pharmacological interventions.

Support assay development and optimization for phenotypic screening and mechanistic studies.

Analyze and interpret experimental data, maintain accurate records, and present findings in team meetings.

Collaborate cross-functionally with scientists in different units.

Contribute to protocol development, SOP documentation, and continuous improvement initiatives.

Qualifications:

Bachelors or Masters degree in Neuroscience, Cell Biology, Stem Cell Biology, or a related field.

LEVEL II - Minimum of 2 years of hands-on experience with human iPSC-derived neuronal cell models and assays.

LEVEL III - Minimum of 5 years of hands-on experience with human iPSC-derived neuronal cell models and assays.

Proficiency in cell-based assay techniques and fluorescence microscopy.

Strong organizational and communication skills.

Ability to work independently and collaboratively in a fast-paced research environment.

Comfortable working with electronic lab notebooks.

Preferred Skills:

Experience with CRISPR editing, RNA-seq, calcium imaging, high-content imaging, or complex co-culture systems is plus.

Knowledge of automated liquid handling systems and high-throughput screening platforms.

Familiarity with cardiometabolic diseases is a plus.

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